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10:57 November 17, 2008 | All news from "Diabetes"

Chemische in kunststof kan veroorzaken fertiliteitsproblemen

Bisfenol A, een chemische stof die wordt gebruikt controversile uitharden van kunststof verpakkingen voor veel voedingsmiddelen en dranken, kunnen invloed hebben op de menselijke voortplanting, onderzoekers verslag.

Bisfenol A (BPA) kunnen schadelijk zijn voor de kans op succesvolle IVF, of de mogelijkheid van embryo’s te hechten aan de baarmoeder, volgens presentaties op de American Society for Reproductive Medicine s jaarlijkse vergadering, waarin wordt geconcludeerd woensdag in San Francisco.

The afgifte van toxische stoffen in het milieu op de mens is erg belangrijk, zei dr. Richard J. Paulson, chef van de Divisie Reproductieve Endocrinologie en infertiliteit aan de Universiteit van Southern California Keck School of Medicine, die niet betrokken was bij het studies.

Vorige maand heeft een Amerikaanse Food and Drug Administration adviespanel zei dat het bureau had gedwaald toen hij zei dat BPA, dat wordt veel gebruikt in baby-flessen en andere plastic verpakkingen voor voedingsmiddelen en dranken, vormt geen gezondheidsrisico’s oplevert. Het agentschap zei dat zij zou waarschijnlijk beginnen vroeg in 2009 tot bepaling van de toxische effecten van BPA over baby’s minder dan 1 maand oud is.

In het eerste rapport, een team geleid door dr. Julie Lamb, van de Universiteit van Californi, San Francisco, gemeten niveaus van BPA in mensen die door hun eerste cyclus van in vitro fertilisatie (IVF). Negentig procent-drie van de 41 vrouwen hadden meetbare BPA niveaus; onder de 31 mannen, 81 procent had kwantificeerbare niveaus van de chemische stof.

De onderzoekers ook gevonden was er een kleine trend onder vrouwen met meetbare BPA een peil dat niet meer zwanger te worden.

Paulson doesn t denk dat deze bevinding is het bewijs dat BPA invloed kan hebben op de kans op succesvolle in vitro fertilisatie.

Most van de vrouwen had detecteerbare niveaus van BPA, wat aangeeft dat BPA is zeker in het verkeer brengen van vrouwen die een vruchtbaarheidsbehandeling ondergaan, zei hij. However, het belang van deze bevinding is nog uncertain.

In een andere presentatie, dr. Shelley Ehrlich van de Harvard School of Public Health en collega’s vinden dat de blootstelling aan BPA had geen invloed op sperma-kwaliteit. De onderzoekers keken BPA niveaus in het sperma van 71 mannen en evalueerde de kwaliteit van het sperma.

Paulson zei dat deze bevinding werd reassuring, hoewel de auteurs doen waarschuwt ervoor dat de studie was klein, en de resultaten dienen te worden beschouwd preliminary.

Reagerend op deze twee studies, Hugh dr. S. Taylor, directeur van de Divisie Reproductieve Endocrinologie en onvruchtbaarheid bij de Yale University School of Medicine, merkte op dat de bevindingen didn t bereiken van de statistische significantie.

This is niet waar ik vermoed bij het vinden van de tekortkomingen met betrekking tot BPA, zei Taylor. BPA lijkt meer zo krachtig als een ontwikkelingstoxiciteit vertoont, zei hij, verwijzend naar prenatale screening en vroegtijdige ontwikkeling.

In de derde studie, dr. Lusine Aghajanova, een postdoc-onderzoeker aan de Universiteit van Californi, San Francisco, belicht uteriene cellen verkregen uit gezonde vrouwen aan BPA in een aantal doses gevonden in de Amerikaanse bevolking.

We opgemerkt dat zelfs op korte termijn blootstelling van die uteriene cellen aan BPA aanzienlijk vermindert de deling van cellen, Aghajanova gezegd. Moreover, onze gegevens wijzen uit dat BPA kan interfereren met de verdere ontwikkeling van uteriene cellen en de manier waarop ze veranderen in voorbereiding op mogelijke pregnancy.

Blootstelling aan BPA kan het voorkomen dat het embryo uit verbonden zijn aan de baarmoeder, Aghajanova gezegd.

Vorige dierproeven hebben gesuggereerd dat BPA mei nabootsing van het vrouwelijk geslachtshormoon oestrogeen. De zorg is dat de blootstelling aan de chemische stof kan leiden tot aangeboren afwijkingen en ontwikkelingsstoornissen bij kinderen.

Blootstelling aan BPA heeft ook verdacht van het veroorzaken tal van andere gezondheidsproblemen, zoals kanker, diabetes, obesitas en aandacht tekort aandoening. BPA blootstelling kunnen ontstaan door direct contact met de chemische of door blootstelling aan voedsel of drank dat in contact is gekomen met materiaal dat BPA.



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Original source: http://healthhh.wordpress.com/2008/11/17/chemische-in-kunststof-kan-veroorzaken-fertiliteitsproblemen/




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